World Wide Web as their primary interface | Honest Reviews Online

In the beginning, a program, called ?client software,? was necessary to handling the mail. There are many different email applications available, some of which cost money to use while others are free; some Internet providers even include it with the service. Client software is still used today, but there is another more flexible method that has become more popular in recent times.
Webmail

In addition to accessing electronic mail through client software, webmail is another popular option. Most service providers offer this as an additional benefit, where the user can access his or her mailbox over the Internet, from any computer or other web-connected device. Some email services are specifically designed for using the World Wide Web as their primary interface. These sites, called ?portals,? have become very popular, as they usually offer individuals a chance to open an email account at no charge, along with access to a search engine, news, calendar, and many other resources from a single spot.
History

Though there is some degree of uncertainty as to when email was invented, the father of the modern version is generally regarded to be an American, Ray Tomlinson. Before Tomlinson, users could send messages to each other, but only when they were connected to the same computer. Even once computers were networked, messages could not be targeted to a particular individual. Tomlinson devised a way to address mail to certain users, and thus was credited for one of the most important communication inventions in the 20th century.

Tomlinson?s idea was to identify the name of the user and the computer at which he or she was located. As a result, the basic formula for addressing an email was username@usercomputer. This standard has not changed much over the years, other than the user computer is now commonly replaced by the name of a service provider.

Grey?s Anatomy Season 8 Episode 24 Finale Online

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Phase I clinical trial shows drug shrinks melanoma brain metastases

ScienceDaily (May 17, 2012) ? An experimental drug targeting a common mutation in melanoma successfully shrank tumors that spread to the brain in nine out of 10 patients in part of an international phase I clinical trial report in the May 18 issue of The Lancet.

The drug dabrafenib, which targets the Val600 BRAF mutation that is active in half of melanoma cases, also cut the size of tumors in 25 of 36 patients with late-stage melanoma that had not spread to the brain. The drug also showed activity in other cancer types with the BRAF mutation.

“Nine out of 10 responses among patients with brain metastases is really exciting. No other systemic therapy has ever demonstrated this much activity against melanoma brain metastases,” said study co-lead author Gerald Falchook, M.D., assistant professor in the Department of Investigational Cancer Therapeutics at The University of Texas MD Anderson Cancer Center.

Melanoma patients whose disease has spread to their brains have a median overall survival of four or five months, the researchers noted. Drugs used to treat brain metastases have response rates of 10 percent or lower. Surgery and stereotactic or whole-brain radiation also are used.

Tumor shrinkage in the nine responders ranged from 20 percent to 100 percent. In four cases, the brain metastases disappeared.

Drug’s reach into brain a surprise

These results will need to be validated in additional clinical trials with larger groups of patients, Falchook said. “This changes how we think of this drug and exclusion criteria for future trials.”

“Most clinical trials exclude patients with brain metastases because the drugs are assumed not to cross the blood-brain barrier,” Falchook said. “These are the patients most in need of a clinical trial because their treatment options are so limited.”

Dabrafenib, made by GlaxoSmithKline, was not designed to cross the blood-brain barrier, which protects the brain from toxic substances in the blood.

The drug’s activity against brain metastases was initially a serendipitous finding at one study site. In one patient, a research PET scan performed just before starting dabrafenib revealed a brain metastasis, but this result was not available until after treatment began. The institution’s ethics board approved the patient to continue treatment because a follow-up PET scan two weeks later showed decreased metabolic activity in the brain metastasis and subsequent MRIs showed a reduction in its size.

The team then designed a sub-study for 10 patients with untreated brain metastases, Falchook said. The mechanism by which dabrafenib reaches tumors in the brain is under investigation.

“In all of these patients with melanoma brain metastases, the tumors eventually progressed,” Falchook said. Prevention of drug resistance remains a challenge in advanced cancers.

High response rate for those without brain metastases

184 patients enrolled at eight sites in the United States and Australia. Of these, 156 patients had melanoma that had spread to other organs. MD Anderson enrolled 64 patients.

The main purpose of a phase I clinical trial is to gradually escalate an experimental drug’s dosage to evaluate side effects and establish the highest possible dose that can be safely given.

The researchers never reached a maximum-tolerated dose limit. No patients had to discontinue the drug due to side effects, and few patients experienced severe toxicity. “This is a very non-toxic drug, which is common with these newer, targeted therapies,” Falchook said.

Based on response rates and the drug’s pharmacokinetics — how the body metabolizes it — the team recommended an oral dose of 150 mg twice daily for future phase II and phase III trials. In the second stage of the phase I trial, they tested that dose in:

  • 36 patients with melanoma with the Val600 BRAF mutation without brain metastases,
  • 10 patients with untreated melanoma brain metastases, and
  • 28 patients with other BRAF-mutant cancers.

Among the 36 melanoma patients without untreated brain metastases:

  • 25 (69 percent) had a partial or complete response, which is shrinkage of at least 30 percent as determined by measuring tumor shrinkage with radiographic imaging,
  • 18 (50 percent) had a confirmed response, meaning the reduction in size was observed in a second imaging scan at least one month later,
  • 17 (47 percent) stayed on the trial for more than six months, and. Responses were seen in the less common Val600Lys BRAF mutation.

The confirmed response rate was similar to that in a phase III study of vemurafenib, the first drug approved for treatment of BRAF-mutant melanoma.

Among those with other types of cancers, patients with papillary thyroid, non-small cell lung and colorectal cancers had partial responses.

“This is further evidence that a tumor’s molecular profile is as important, and possibly more important, than the organ where the cancer begins,” Falchook said.

“We need to screen for BRAF and other molecular abnormalities in our patients’ tumors,” he said. “In many other tumor types BRAF mutations occur in small percentages of patients. If we’re not testing for it routinely, these patients might never be treated with a promising targeted agent for their cancer.”

Falchook has six melanoma patients still receiving dabrafenib, including five who are in complete remission. In addition, Falchook is still treating six papillary thyroid patients and one colorectal cancer patient whose tumors have not progressed on the treatment.

GlaxoSmithKline sponsored and funded the clinical trial. Phase II and phase III trials of dabrafenib for melanoma are under way.

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Story Source:

The above story is reprinted from materials provided by University of Texas M. D. Anderson Cancer Center.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Gerald S Falchook et al. Dabrafenib in patients with melanoma, untreated brain metastases, and other solid tumours: a phase 1 dose-escalation trial. The Lancet, Volume 379, Issue 9829, Pages 1893 – 1901, 19 May 2012 DOI: 10.1016/S0140-6736(12)60398-5

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

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Video: A View From the Trading Pits: Deflation Ahead?

Scott Shellady, Bradford Capital Management CEO, provides a preview of what traders are watching ahead of the market’s open, and weighs in on Greek debt, earnings, inflation & deflation, commodities and the direction of the economy.

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A Twist In Real Estate Marketing | Logan Home Search

Marketing ideas and strategies are constantly changing due to changing technologies, lifestyle and demands of consumers. What was effective in the past may not be as effective in the future. Thus, the marketing ideas that you employ need to be creative and effective. Real estate agents in this matter need to think outside the box. Moreover, it should prompt a buyer to take a second look at the property. Take note that the rate of selling?California real estate vary so, real estate agents should employ marketing ideas that are timeless yet effective in constantly bringing in serious home buyers all year round.

What are examples of creative marketing ideas? Try adding a picture of the property your are selling in business cards and don?t forget to make it colorful. Think something creative and cute when it comes to giveaways like key chains, magnets, stickers, notepads, pencils or pens or you can print t-shirts with some colorful information

There are a lot of marketing ideas like content management, website content writing, graphic design, property branding, online promotions, PPC or pay per click advertising setup and maintenance, podcast production and marketing, webpage sales copy writing, web traffic analytics setup and a whole lot more.

Real estate agents also write articles regarding the properties where the property has a link and submitted to local Internet directory sites. They also participate in real estate forums, create social network accounts, submit their sites to social bookmarking sites, article directories, and RSS feeds.

Since there is a change in Google?s search results ranking algorithm, real estate agents should see to it that their real estate websites are in good quality, great design, trustworthy, not sending our too many links. A lot of websites have been affected by this Panda update and should be taken into serious condition by agents specializing in marketing. Moreover, make sure that the marketing ideas you are using are not outside of Google?s guidelines.

These are good strategies for a successful marketing.? Houses for sale will not be sold unless one employs effective marketing tools. Explore creative marketing ideas and discover that marketing is a whole lot easier.

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Essential Information telephone systems … – CareCrunch Answers

Cell phone methods turned out to be a part of company marketing and sales communications essentially as soon as they will came to be in excess of Century returning. Regarding relating to eco-friendly 100 years, almost all info along with telephone calls put on accounts associated with place of work interconnection techniques ended up made the exact same strategy. An enterprise concern director could possibly phone somebody from the landline mobile phone that observed men and women contact number multi-level. By way of wireline technologies, organization deals have been connected in addition to done earlier mentioned One devoted earth that always been offered until finally these kinds of event as an personal meet up concluded your choice. Given that small businesses higher to help you function consumers in addition to assist vendors previous their unique community places and in addition face-to-face discussion had been lost, frequent landline cell phone strategies turned out to be an expensive need to have with regard to finishing business out of long-distance installments, bad cable connections and also other pieces of the way.

By which altered the moment installers plus discussion elements helps make observed means of convert mobile phone relationships right into information deals : up-and-coming small to mid-sized items connected to electronic info the same as people that computer systems make use of to help speak. After become information packets, cell phone conversations could be carried just about anyplace that personal computer info boxes may possibly receive : such as World-wide-web. This kind of started off everyone as well as Internet telephone systems.

At times termed as Voice over ip (with respect to be able to Words close to Net Method), Net phone purges obsolete limits. Through Voice over internet protocol technical know-how, business office partnership remedies are generally won?t limited to your present restrictions from the common cell phone multi-level begin a worldwide as well as options regarding firm website link productivity. For example, Ip mobile phone tactics can easily link mobile phone shoppers worldwide, making it possible for some sort of product sales business office representative to keep soothing in a very component office all through Street. Louis along with Wa, by using an Above cellular phone that is an authentic proxy servers through the corporation?s home office after only Austin. Additionally, Voip know-how operating an enterprise cell phone factors will allow for companies as a way to plug extensions close to A hundred office office buildings before home office by way of one specific sales and marketing communications treatments.

Utilizing Above mobile phone strategies accessible, these kind of a number of aspect office buildings, along with handheld remote control males and females, may well immediately connect mutually, properly generating an individual large place of work interaction technique. Consequently, this kind of person spots can provide basically each of the very same opportunities because the plug-ins attached nonetheless workplace not having vacation cut-off dates, consequently raising corporation solutions by utilizing sophisticated marketing and sales communications together with Ip telephone options.

Check out the best telephone systems and see the awesome managed communication services

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Josh Hamilton?s Evolution Into Baseball?s Tim Tebow

Josh Hamilton publicly cites his faith as a main reason for his recovery from alcohol and drug abuse. (credit: Mitchell Layton/Getty Images)

Josh Hamilton publicly cites his faith as a main reason for his recovery from alcohol and drug abuse. (credit: Mitchell Layton/Getty Images)

DALLAS (CBSDFW.COM)???He?s known as ?Hambone,? ?The Hammer,? ?Hambino,? and ?The Natural.? His reputation of ?formers? ? former No. 1 overall pick, former drug addict, former alcoholic, former Home Run Derby king and former MVP ? precedes him. His four home-run outing last week at Camden Yards has helped fuel an early-season run at another MVP, coinciding with his Texas Rangers? run at a third straight World Series appearance.

By now, not much will surprise fans and critics alike when it comes to the success or adversity faced by Josh Hamilton. Yet, somewhere along the line, something happened that perhaps gets ignored for one reason or another: Hamilton, one of the most feared hitters in baseball and a man of faith, has become Major League Baseball?s version of Tim Tebow.

Their paths toward their very public lives that highlight their faith have been different ? Tebow growing up in an evangelical home and Hamilton finding his faith during his rehab for drug and alcohol abuse. Tebow?s presence as an NFL quarterback has been met with differing opinions of rabid fans and detractors alike, and that occasionally overlaps with his faith. Describing Tebow as ?polarizing? has been muddled in meaning, the conversation evolving, at times, from whether Tebow can be a legitimate NFL quarterback to whether his in-your-face approach in regard to faith is too much. But polls like the?January 2012 survey from Poll Position, which found that 43 percent of people polled believe that God helped with Tebow?s success last season, will keep that definition of ?polarizing? alive in a society that is not solely Christian. It was all a part of last season?s Tebowmania, featuring the nationwide craze of ?Tebowing,? paying homage to the inexplicable story of Tebow leading the Denver Broncos to a playoff spot despite what critics have defined as a limited skill set.

?Regardless of what happens, I still honor my Lord and Savior Jesus Christ, because at the end of the day, that?s what?s important,? Tebow said last month at an Easter Sunday service in Austin. ?We need to get back to one nation under God, and be role models for kids.?

Hamilton takes a more low-key approach to his faith and that plays to the benefit of his quiet, understated personality. The story of his past problems and the unforeseeable rebound that followed have been well-chronicled. The convergence of Hamilton?s rise to superstardom and the rediscovery of his faith have happened in a baseball town that has enjoyed the most successful run of the Rangers? history, which has helped make his faith a detail in Arlington, ?compared to what it could be in another larger market. There are times, however, like last week in Baltimore after his historic four home-run night, in which his faith?s role is unavoidable in conversation.

?I think about what God?s done in my life, everything I did to mess it up,? Hamilton told?ESPN?last week. ?What God has allowed me to do, to come back from everything I?ve been through and still be able to play the game at the level I play it ? it?s pretty amazing to think about that.

?To finally surrender everything and pursue that relationship with Christ on a daily basis and understanding when I don?t pursue it, I end up messing up. Understanding that what I?m doing and what God?s allowed me to do, coming back from everything I went through and allowing me to play the game at the level I play it, it?s pretty amazing to think about.?

And both players continue to enjoy immense popularity. In January, Tebow, who has almost 2 million likes on his Facebook page, was voted the?most popular athlete in America in a poll conducted by ESPN. Hamilton?s jersey was the fourth highest-selling MLB jersey in 2011, trailing only Derek Jeter, Cliff Lee and Albert Pujols, according to?MLB and the MLB Players Association.

But both men are either at a crossroad or will be approaching one shortly. Tebow is adjusting to life as a backup quarterback after being traded to New York, which has made Tebow, the evangelical quarterback in a city with a melting pot of religious and faith beliefs, its newest, shiny toy for the media to dissect. At season?s end, Hamilton will be a free agent, assuming the role of top prize on the open market. He doesn?t have to say what role his faith could play in free agency, not when his teammates are saying it for him.

?Josh isn?t a guy who cares about money,? Rangers outfielder?David Murphy told ESPN of Hamilton?s impending free agency and MVP start to the season. ?He?s put the Lord first, and everything else goes from there. You see a lot of guys play well in their ?walk? year before they go to free agency, and it?s obvious why they?re motivated. I think this is more of a coincidence than anything.?

In February of this year, Hamilton announced he had suffered an alcohol relapse. It was an embarrassing day, addressing how he would recover. He knew he could have just blown his chance at one last mega-contract from the Rangers or anyone else, but that wasn?t the issue. His issue was with what was ahead of him. Hamilton may keep to himself and may never be the evangelical figure that Tebow has become to the sports culture, but there?s not as much as a whimper in arguing against the notion that Hamilton means just as much ? and maybe even more ? to the discussion of faith?s role in sports.

?How hard I play on the field is how hard I have to focus on my recovery, which is the Lord,? Hamilton said?that day, uncertain of his future or the season he was about to have. ?I ask everyone who is watching to pray for me and my family because it never gets easy.?

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Playful games promote reading development

[ Back to EurekAlert! ] Public release date: 14-May-2012
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Contact: Ulrika Wolff
ulrika.wolff@ped.gu.se
46-031-786-2219
University of Gothenburg

Short but intense training sessions in the form of structured language games from the age of four can stimulate children’s early language development and may also make it easier for children to learn to read. This is found in a current research project at the University of Gothenburg, Sweden.

Previous research has shown that children’s reading development can be stimulated with structured and playful language games from the age of six. In a current three-year study, researchers at the University of Gothenburg are exploring the effects of having children as young as four participate in such games. The hypothesis is that young children who are actively stimulated in their development of so-called linguistic and phonological awareness end up better prepared for dealing with written language. Linguistic awareness means that the child is aware of his or her own language, what it sounds like and how it consists of words and sentences. Phonological awareness implies an awareness of the sound structure of the language, which is important for the early stages of reading development and for understanding the connection between letters and sounds.

The study includes 370 children as well as a number of pre-school and special needs teachers in eight municipalities. The studied children receive phonological training for 25 minutes a day for six weeks. The six-week period is repeated with the same children for a total of three years, with pre- and post-tests during the three years. The children are divided into three groups one phonological group, one group receiving alternative training, and one control group that is not receiving any particular training. In the third and final year, all three groups are offered phonological training within the framework of the regular pre-school work.

The preliminary findings indicate that the phonological training had an effect immediately following the training, and that the effect can be observed one year later as well.

‘The children in the intervention group had a higher level of phonological awareness. They were for example able to identify and manipulate speech sounds. Rhyming is one example of this. The ability to recognise the form of the language is something that researchers know is important for early reading development,’ says Senior Lecturer Ulrika Wolff, who is heading the project together with Professor Jan-Eric Gustafsson.

Since the studied children are still in pre-school, they are not yet being taught the art of reading. The researchers are planning to follow the same group of children for a few years once they start school in order to investigate the more long-term effects of early intervention on the development of reading and writing skills. Doing so will show whether or not the children who have not received the training are able to catch up with the intervention group.

###


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?

AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

[ Back to EurekAlert! ] Public release date: 14-May-2012
[ | E-mail | Share Share ]

Contact: Ulrika Wolff
ulrika.wolff@ped.gu.se
46-031-786-2219
University of Gothenburg

Short but intense training sessions in the form of structured language games from the age of four can stimulate children’s early language development and may also make it easier for children to learn to read. This is found in a current research project at the University of Gothenburg, Sweden.

Previous research has shown that children’s reading development can be stimulated with structured and playful language games from the age of six. In a current three-year study, researchers at the University of Gothenburg are exploring the effects of having children as young as four participate in such games. The hypothesis is that young children who are actively stimulated in their development of so-called linguistic and phonological awareness end up better prepared for dealing with written language. Linguistic awareness means that the child is aware of his or her own language, what it sounds like and how it consists of words and sentences. Phonological awareness implies an awareness of the sound structure of the language, which is important for the early stages of reading development and for understanding the connection between letters and sounds.

The study includes 370 children as well as a number of pre-school and special needs teachers in eight municipalities. The studied children receive phonological training for 25 minutes a day for six weeks. The six-week period is repeated with the same children for a total of three years, with pre- and post-tests during the three years. The children are divided into three groups one phonological group, one group receiving alternative training, and one control group that is not receiving any particular training. In the third and final year, all three groups are offered phonological training within the framework of the regular pre-school work.

The preliminary findings indicate that the phonological training had an effect immediately following the training, and that the effect can be observed one year later as well.

‘The children in the intervention group had a higher level of phonological awareness. They were for example able to identify and manipulate speech sounds. Rhyming is one example of this. The ability to recognise the form of the language is something that researchers know is important for early reading development,’ says Senior Lecturer Ulrika Wolff, who is heading the project together with Professor Jan-Eric Gustafsson.

Since the studied children are still in pre-school, they are not yet being taught the art of reading. The researchers are planning to follow the same group of children for a few years once they start school in order to investigate the more long-term effects of early intervention on the development of reading and writing skills. Doing so will show whether or not the children who have not received the training are able to catch up with the intervention group.

###


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?

AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.

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REALTOR.com Expanding To Video On Demand in 2012 …

REALTOR.com Expanding To Video On Demand in 2012 photo

Realtor.com today announced an agreement to launch the Realtor.com Channel powered by the Home Tour Network, part of the RealBizMedia?s group.

The new Realtor.com Channel will launch in the second half of 2012 and bring millions of property listings into 55 million U.S. homes starting with the Cox cable network. In doing so, Realtor.com will be the first company to deliver a real estate search experience on the three screens consumers use most: computer, mobile and TV. Executives are discussing plans to expand the channel into other networks.

?Realtor.com is continually improving the real estate search experience with emerging technologies to make it easier for millions of people to connect with real estate professionals ready to help them find the home that?s right for their family,? said Steve Berkowitz, Move?s chief executive officer. ?With ?for-sale? inventories down across the nation, having convenient, fast and fun search options, along with the partnership of a professional agent, is important. When the Realtor.com Channel has launched, regardless of where you are or what you?re doing, Realtor.com will be with you.?

The Realtor.com Channel will be a powerful way for real estate agents to reach home buyers on a highly geo-targeted level. Based on location, property listings on the Realtor.com Channel will be displayed by price range delivered by the Home Tour Network and include high quality photo-based videos and descriptions provided by agents. With just a few clicks of the remote, viewers can instantly connect with agents for information.

?We?re excited to be teaming up with Realtor.com on this new venture that will help millions of people find what we hope becomes their piece of the American Dream ? a home,? said Steve Marques, CEO of RealBizMedia. ?Our experience in launching our propriety video platform positions RealBizMedia to leverage both organizations? assets and provide home buyers and folks simply interested in checking out the local market with a new way to discover real estate and connect with real estate experts across the country.?

Only Realtor.com listings ? the freshest and most accurate collection of real estate listings available ? will appear on the new Realtor.com Channel. All listings on Realtor.com are sent to the site directly from more than 850 MLSs across the nation. Approximately 85 percent of the listings on Realtor.com are updated every 15 minutes by the MLSs with the remainder updated every one to 24 hours.

Today?s VOD platform makes it possible for millions of potential buyers who subscribe to cable television to discover for-sale listings as part of their entertainment viewing experience. With the rapid adoption of technologies that enable seamless navigation between TV to internet content, Realtor.com is now positioned to create even richer experiences and more opportunities for consumers, agents and advertisers to connect conveniently and on demand.

An exclusive media program will soon be developed for general advertisers interested in reaching millions of cable subscribers across the nation through the Realtor.com Channel. The financial terms of the agreement were not disclosed.

Related posts:

  1. New Feature: Log In To Realtor.com With Your Facebook Account
  2. REALTOR.com Goes Global, Launches International Site
  3. SocialBios Now in Beta on REALTOR.com ? Sign Up Now!
  4. How To Get Internet In Every Room Of Your House: Tecca Tuesday Tech Update
  5. REALTOR.com iOS Apps Updated: New Data, New Home Screen Experience

About Scott Garner

Scott Garner is Editor in Chief of REALTOR.com Blogs and Social Media Supervisor for Move, Inc.

View all articles by Scott Garner

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Ex-Murdoch editor charged over UK phone-hacking scandal

LONDON (Reuters) – Rebekah Brooks, a close confidante of Rupert Murdoch, was charged on Tuesday with interfering with a police investigation into a phone hacking scandal that has rocked the tycoon’s media empire and sent shockwaves through the British political establishment.

Brooks, 43, was charged with concealing material from detectives, conspiring to remove boxes of archive records from Murdoch’s London headquarters, and hiding documents, computers and other electronic equipment from the police. If found guilty she could face a prison sentence.

The charges are the first since police re-launched an investigation into alleged illegal practices at Murdoch’s British newspapers following accusations the extent of wrongdoing had been covered up.

The news is a personal blow for the world’s most powerful media boss and also embarrassing for British Prime Minister David Cameron, who was close friends with Brooks and sent her text messages of support when the alleged offences took place.

The action against Brooks comes as Murdoch is increasingly under fire in Britain. He has been forced to close one newspaper, withdraw a major takeover bid for a TV station and been described by a parliamentary committee report as someone who is not fit to run a major international company.

Murdoch’s closeness to Brooks, instantly recognizable for her mane of flame-red hair, was highlighted last year, when the mogul flew into London to tackle the hacking scandal, put his arm around her and declared that she was his top priority.

“I have concluded … there is sufficient evidence for there to be a realistic prospect of conviction,” said Alison Levitt, Principal Legal Advisor to Britain’s Director of Public Prosecutions in a rare televised statement.

“All these matters relate to the ongoing police investigation into allegations of phone hacking and corruption of public officials in relation to the News of the World and The Sun newspapers,” Levitt said.

Also charged were Brooks’s racehorse trainer husband Charlie Brooks, her secretary and other staff including her driver and security officials from News International, the British newspaper arm of Murdoch’s News Corp media empire.

The maximum sentence for perverting the course of justice is theoretically a life prison term although such a lengthy sentence would be unlikely.

“We deplore this weak and unjust decision,” Rebekah and Charlie Brooks, who was at school with Cameron at the exclusive Eton College, said in a statement.

Rebekah Brooks was on Tuesday being questioned at a London police station. There was no comment from Cameron’s office.

SYMBOLIC

“This is a symbolic moment for British media and politics,” Ivor Gaber, professor of political journalism at London’s City University, told Reuters.

“This yet again raises questions about the prime minister’s judgment, that he chose to associate both professionally and socially with somebody who is facing charges which could result in imprisonment.”

The phone-hacking scandal first broke six years ago when the royal correspondent from the News of the World, a Sunday tabloid, and a private detective were arrested and later jailed for hacking the phones of aides to the royal family.

News International maintained the practice was limited to one rogue reporter until that defense crumbled last year as detectives reopened their investigation amid claims their initial probe had been insufficient.

About 160 officers are examining claims that journalists at the News of the World routinely hacked into the phones of hundreds of celebrities, politicians and victims of crime to generate front-page stories.

They are also investigating whether staff hacked into computers and made illegal payments to public officials, including the police, to get ahead in their reporting.

Almost 50 people have been arrested, with a tax official and a woman the latest to be held by detectives on Tuesday morning.

SAGA

The explosive saga has shone a light on close ties between the media, British politicians and the police, with Brooks one of the central characters.

Ministers who previously overtly courted Murdoch and the backing of his papers turned on the mogul last year, forcing the 81-year-old to withdraw a $12 billion bid for lucrative British pay TV group BSkyB.

Cameron admitted he had ridden a horse given to Brooks by the police in the company of her husband, which critics seized on as evidence as an overly cozy relationship. He also attended a Christmas party at the couple’s house in 2010, at a time when the government was considering whether to approve the BSkyB deal.

Dubbed by some Murdoch’s “fifth daughter”, Brooks edited the News of the World from 2000 to 2003 and went on to become the first female editor of the Sun daily tabloid, Britain’s most widely read newspaper, for six years. Murdoch closed the 168-year-old News of the World last year as a result of the scandal.

With her close links to the upper echelons of the British establishment including a string of prime ministers and senior police officers, Brooks was promoted to run Murdoch’s British newspaper arm from 2009 to 2011.

Brooks had close ties with Cameron’s predecessor as prime minister, Gordon Brown, whose wife Sarah hosted a ‘pyjama party’ in 2008 that was attended by Brooks and Murdoch’s wife Wendi and daughter Elisabeth.

But Brooks was forced to stand down last July under a tide of revelations about phone hacking, and was arrested two days later over allegations of interception of communications, and corruption.

She was detained again in March this year, along with her husband, over the allegations relating to perverting the course of justice. Detectives have not concluded their investigations into the other potential offences.

During day-long questioning at a public inquiry into media ethics last week, Brooks said that she and Cameron had frequently exchanged text messages and would occasionally sign them off “LOL”, by which he meant “lots of love”.

Cameron is already facing questions over why he hired Andy Coulson, Brooks’s successor as News of the World editor, as his media chief. Coulson, who quit that role in January 2011, is amongst those to have been arrested.

“My wish is that the police had done a proper investigation right back in the beginning, because then all of this could have been done and dusted ages ago,” said Chris Bryant, an opposition lawmaker and one of the hacking victims.

“I fear the prime minister will have some questions to answer about the kind of company he has been keeping,” he told Reuters.

The others charged on Tuesday were Cheryl Carter, Brooks’s personal assistant, Mark Hanna, the Head of Security at News International, Paul Edwards, her chauffeur, and Daryl Jorsling, who provided security for Brooks.

(Additional reporting by Tim Castle and Clare Kane; Editing by Guy Faulconbridge and Giles Elgood)

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